Method of determining the sensitivity of cancer cells to EGFR inhibitors including cetuximab, panitumumab and erlotinib
AssigneeMontefiore Medical Center
InventorsJohn M. Mariadason, Sanjay Goel
Life of this patent
Estimating the term…
Abstract
A method of determining if a cancer patient is amenable to treatment with EGFR inhibitors including but not limited to cetuximab, panitumumab or erlotinib by the following steps: (a) Obtaining cells from a cancer patient's tumor; (b) Determining if said cells contain a biomarker that is predictive of a therapeutic response to response to treatment with cetuximab or panitumumab. The biomarker is the mutation status of the PIK3CA gene and the expression status of the PTEN gene. Tumors that harbor activating mutations in Exon 9 and 20 of the PIK3CA gene or which show loss of PTEN protein expression will be considered not likely to benefit from EGFR targeting therapies.
Claims11
A method of determining if a cancer patient is amenable to treatment with an EGFR inhibitor which comprises determining the mutation status of the PIK3CA gene in a tumor from the cancer patient, wherein an activating mutation in the PIK3CA gene is indicative that the patient is not likely to benefit from treatment with the EGFR inhibitor.
Dependencies are inferred from the claim text.