Preparation of controlled release skeletal muscle relaxant dosage forms

A method of preparing a pharmaceutical composition comprising:

• a) coating inert particles with a drug layering composition comprising cyclobenzaprine or a pharmaceutically acceptable salt, solvate, and/or ester thereof, and a pharmaceutically acceptable solvent, thereby forming IR beads;
• b) coating the IR beads with an ER coating composition comprising a pharmaceutically acceptable water-insoluble polymer, under an atmosphere having a dew point ranging from about 5-20° C., thereby forming ER beads;
• and
• c. curing the ER beads at about 60° C. for about 4-12 hours under an atmosphere having a dew point ranging from about 5-20° C.