Treating idiopathic thrombocytopenic purpura with comprising extracts of Astragalus membranaceus
AssigneeEcoPharm, LLC
InventorsJinhua An, John M. Fidler, John H. Musser
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Abstract
The teachings provided herein generally relate to the preparation and uses of compositions comprising extracts of Astragalus membranaceus. The extracts are prepared from Astragalus membranaceus and can comprise, for example, an acid-modified arabinogalactan protein composition having an arabinose:galactose ratio ranging from about 3.5:1 to about 5.0:1, from about 5% to about 10% rhamnose, from about 15% to about 20% galactose, and from about 10% to about 15% glucose. The compositions can be used in the treatment of idiopathic thrombocytopenic purpura and the formulation of medicaments for such treatments.
Claims12
A composition comprising a purified extract of the roots of Astragalus membranaceus, wherein the extract comprises:
- an arabinose:galactose ratio greater than 4.0:1 to 5.0:1;
- from about 5% to about 10% rhamnose;
- from about 15% to about 20% galactose;
- from about 10% to about 20% galacturonic acid;
- not more than 2% by weight protein, and,
- from about 10% to about 15% glucose;
- wherein,
- the extract is prepared using a first process that includes isolating a crude extract from Astragalus membranaceus and mildly treating the crude extract with an acid, the mildly treating including applying the acid to the crude extract at a concentration ranging from about 0.05M to about 0.5M, at a temperature ranging from about 15° C. to 25° C., and for a time ranging from about 1 hour to about 24 hours, wherein the temperature and time for applying the acid are selected to obtain the arabinose:galactose ratio, the galactose content, the glucose content, and a high yield;
- and,
- the extract is substantially higher in yield than an extract of the Astragalus membranaceus produced using a second process that includes applying the acid to the crude extract at a temperature and time selected to obtain an arabinose:galactose ratio of less than 3.5:1, 20%-35% galactose, and less than about 10% glucose.
Dependencies are inferred from the claim text.