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US 8,137,697 B1Granted
Nanoparticles for protein/peptide delivery and delivery means thereof
AssigneesGP Medical, Inc., National Tsing Hua University
InventorsHsing-Wen Sung, Mei-Chin Chen, Po-Wei Lee, Hosheng Tu
Life of this patent
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Abstract
The invention discloses the biodegradable nanoparticle for use in nanoparticle projectile bombardment as a carrier for administering nucleic acid, DNA, RNA or siRNAs transdermally to an animal subject. The nanoparticles are composed of positively charged chitosan substrate and the nucleic acid encapsulated within the nanoparticles or electrostatically loaded on the exterior surface of the nanoparticles.
Claims19
A pharmaceutical composition of nanoparticles encapsulating a therapeutically effective amount of at least on bioactive agent, each nanoparticle comprising:
- a first component of a positively charged chitosan, a second component of a negatively charged substrate that complexes with said first component, at least one quantum dot in a core portion of said nanoparticles, and said at least one bioactive agent, wherein said bioactive agent is encapsulated within said nanoparticles, said nanoparticles having a mean particle size between about 50 and 500 nanometers.
Dependencies are inferred from the claim text.