Immediate release and sustained release ibuprofen dosing regimen
AssigneeMcNeil-PPC, Inc.
InventorsDer-Yang Lee, Frank Bunick, James Schwing
Life of this patent
Estimating the term…
Abstract
A method of administering non-steroidal-anti-inflammatory drugs, in particular propionic acid derivatives such as ibuprofen, is provided. The inventive dosage forms provide an initial release of the NSAID and a second sustained release of NSAID, preferably in a single dosing step.
Claims9
A dosage form capable of providing relief of pain over a 12 hour period, comprising an immediate release portion comprising about 200 mg to about 400 mg of an immediate release dose of ibuprofen, wherein said immediate release dose is released at the beginning of said 12 hour period, and a sustained release portion comprising about 100 mg to about 200 mg of a sustained release dose of said ibuprofen, wherein said sustained release dose is released about 2 hours to about 10 hours after release of said immediate release dose, and wherein said immediate release portion contains a dose that is at least about twice the dose in the sustained release portion.
Dependencies are inferred from the claim text.