4-aza-caprolactone-based polymeric compositions useful for the manufacture of biodegradable medical devices and as medical device coatings
AssigneeMedtronic Vascular, Inc.
InventorsMingfei Chen, Peiwen Cheng, Kishore Udipi
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Abstract
N-substituted 4-aza-caprolactone biodegradable polymers, including derivatives thereof, useful for making implantable medical devices and coatings therefore are provided. The medical devices and coatings of the present invention can also be used for in situ controlled release drug delivery and are useful for treating or preventing medical conditions such as restenosis, aneurisms and vulnerable plaque.
Claims27
A medical device comprising:
- a biodegradable polymer wherein at least one monomeric unit is derived from the compound of Formula I:
- wherein R is a hydrogen, a straight chain or branched C1-C18 alkyl, a C3-C18 cycloalkyl, a straight chain or branched C2-C18 alkenyl or alkynyl, a straight chain or branched C1-C18 alkoxy, an aryl, protected carboxyl, a substituted or unsubstituted amino group, an amino acid residue, or hydroxyl.
A vascular stent comprising:
- a biodegradable polymer wherein at least one monomeric unit is derived from the compound of Formula I:
- wherein R is a hydrogen and said biodegradable polymer further comprises a bioactive agent.
An implantable medical device having a controlled release coating comprising a biodegradable polymer wherein at least one monomeric unit is derived from the compound of Formula I:
- wherein R is a hydrogen and said biodegradable polymer further comprises a zotarolimus.
A biodegradable implantable medical device comprising a biodegradable polymer wherein at least one monomeric unit is derived from the compound of Formula I:
- wherein R is a hydrogen and said biodegradable polymer further comprises a zotarolimus.
A vascular stent having a controlled-release coating comprising an amphiphilic, biocompatible, biodegradable polymer wherein at least one monomeric unit is derived from the compound of Formula I:
- wherein R is a hydrogen and said biodegradable polymer further comprises a zotarolimus.
A biodegradable vascular stent comprising a biodegradable polymer wherein at least one monomeric unit is derived from the compound of Formula I:
- wherein R is a hydrogen and said biodegradable polymer further comprises a zotarolimus.
A monomer suitable for use in making a polymeric compound comprising the compound of Formula I:
- wherein R is a hydrogen, a straight chain or branched C1-C18 alkyl, a C3-C18 cycloalkyl, a straight chain or branched C2-C18 alkenyl or alkynyl, a straight chain or branched C1-C18 alkoxy, an aryl, protected carboxyl, a substituted or unsubstituted amino group, an amino acid residue, or hydroxyl.
A biodegradable polymer comprising a compound according to Formula II:
- wherein a:b:c:d are repeating units and wherein a=0-20,000, b=1-20,000, c=1-2000 and d=0-20,000 and R is a hydrogen, a straight chain or branched C1-C18 alkyl, a C3-C18 cycloalkyl, a straight chain or branched C2-C18 alkenyl or alkynyl, a straight chain or branched C1-C18 alkoxy, an aryl, protected carboxyl, a substituted or unsubstituted amino group, an amino acid residue, or hydroxyl.
A biodegradable polymer comprising a compound according to Formula III:
- wherein a:b:c are repeating units and wherein a=0-20,000, b=1-2000 and c=1-20,000 and R is a hydrogen, a straight chain or branched C1-C18 alkyl, a C1-C18 cycloalkyl, a straight chain or branched C2-C18 alkenyl or alkynyl, a straight chain or branched C1-C18 alkoxy, an aryl, protected carboxyl, a substituted or unsubstituted amino group, an amino acid residue, or hydroxyl.
A biodegradable polymer comprising a compound according to Formula IV:
- wherein a:b:c are repeating units and wherein a=0-20,000, b=1-20,000 and c=1-20,000 and R is a hydrogen, a straight chain or branched C1-C18 alkyl, a C3-C18 cycloalkyl, a straight chain or branched C2-C18 alkenyl or alkynyl, a straight chain or branched C1-C18 alkoxy, an aryl, protected carboxyl, a substituted or unsubstituted amino group, an amino acid residue, or hydroxyl.
A polymer comprising the monomer according to Formula I and at least one other polymer repeating unit selected from the group consisting of δ-caprolactone, dioxanone, trimethyl carbonate, amino acids, peptides and combinations thereof.
Dependencies are inferred from the claim text.