Hyaluronic acid compound, hydrogel thereof and joint treating material
AssigneeTeijin Limited
InventorsEiichi Kitazono, Hiroaki Kaneko, Masaya Ito, Chiaki Fukutomi, Saki Tsuzuki, Yoshihiko Sumi
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Abstract
A hyaluronic acid compound which is a reaction product between hyaluronic acid and a phosphatidyl ethanolamine. This compound has biocompatibility and bio-safety, and can be formed into a hydrogel or molded form having a certain shape. Making use of these properties, it is used to treat a knee joint, prevent the accretion of a tissue after an operation and keep a skin wet.
Claims9
A hyaluronic acid compound represented by the following formula (1)′:
- wherein R0 is a group represented by the following formula (1)′-a, —OH or —ONa,
- wherein R01 is an alkenyl group having 10 to 28 carbon atoms, and n is an integer of 50 to 50,000, with the proviso that 1 to 50% of R0 is the group represented by the above formula (1)′-a, said hyaluronic acid compound showing a complex elastic modulus of more than 200 Pa with its hydrogel having a concentration of 3 wt %.
A joint treating material comprising a hyaluronic acid compound represented by the following formula (1)′:
- wherein R0 is a group represented by the following formula (1)′-a, —OH or —ONa,
- wherein R01 is an alkenyl group having 10 to 28 carbon atoms, and n is an integer of 50 to 50,000, with the proviso that 1 to 50% of R0 is the group represented by the above formula (1)′-a, said hyaluronic acid compound showing a complex elastic modulus of more than 200 Pa with its hydrogel having a concentration of 3 wt %.
A method of using a hyaluronic acid compound comprising inserting a joint treating material prepared from a hyaluronic acid compound represented by the following formula (1)′:
- wherein R0 is a group represented by the following formula (1)′-a, —OH or —ONa,
- wherein R01 is an alkenyl group having 10 to 28 carbon atoms, and n is an integer of 50 to 50,000, with the proviso that 1 to 50% of R0 is the group represented by the above formula (1)′-a, said hyaluronic acid compound showing a complex elastic modulus of more than 200 Pa with its hydrogel having a concentration of 3 wt %,
- into the joint of a patient.
Dependencies are inferred from the claim text.