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US 8,137,677 B2Granted
Non-protein stabilized clostridial toxin pharmaceutical compositions
AssigneeAllergan, Inc.
InventorTerrence J. Hunt
Life of this patent
Estimating the term…
Abstract
A Clostridial toxin pharmaceutical composition comprising a Clostridial toxin, such as a botulinum toxin, wherein the Clostridial toxin present in the pharmaceutical composition is stabilized by a non-protein excipient such as a polyvinylpyrrolidone, a disaccharides, a trisaccharide, a polysaccharide, an alcohol, a metal, an amino acid, a surfactant and/or a polyethylene glycol.
Claims12
A pharmaceutical composition comprising:
- (a) a botulinum toxin,
- (b) about 5 mg to about 20 mg of a polyvinylpyrrolidone for each about 100 units of the botulinum toxin, and
- (c) about 0.5 mg to about 250 mg of lactose,
- wherein the potency of the botulinum toxin is at least about 40% to about 50% of the theoretical maximum potency of the botulinum toxin.
1 more element
A pharmaceutical composition comprising:
- (a) a botulinum toxin,
- (b) about 5 mg of a polyvinylpyrrolidone for each about 100 units of the botulinum toxin, and
- (c) about 5 mg of lactose,
- wherein the potency of the botulinum toxin is at least about 50% of the theoretical maximum potency of the botulinum toxin.
1 more element
A pharmaceutical composition comprising:
- (a) a botulinum toxin, wherein the botulinum toxin is not stabilized by a protein excipient,
- (b) about 20 mg of a polyvinylpyrrolidone for each about 100 units of the botulinum toxin, and
- (c) about 5 mg to about 250 mg of lactose,
- wherein the potency of the botulinum toxin is at least about 40% of the theoretical maximum potency of the botulinum toxin.
1 more element
A pharmaceutical composition comprising:
- (a) a botulinum toxin, wherein the botulinum toxin is not stabilized by a protein excipient,
- (b) about 10 mg of a polyvinylpyrrolidone for each about 100 units of the botulinum toxin, and
- (c) about 0.5 mg to about 250 mg of lactose,
- wherein the potency of the botulinum toxin is at least about 50% of the theoretical maximum potency of the botulinum toxin.
1 more element
Dependencies are inferred from the claim text.