Genetically engineered equine influenza virus and uses thereof
AssigneesMount Sinai School of Medicine, University of Kentucky
InventorsPeter Palese, Adolfo Garcia-Sastre, Thomas Chambers
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Abstract
The present invention relates, in general, to attenuated equine influenza viruses having an impaired ability to antagonize the cellular interferon (IFN) response, and the use of such attenuated viruses in vaccine and pharmaceutical formulations. In particular, the invention relates to attenuated equine influenza viruses having modifications to an equine NS1 gene that diminish or eliminate the ability of the NS1 gene product to antagonize the cellular IFN response. These viruses replicate in vivo, but demonstrate decreased replication, virulence and increased attenuation, and therefore are well suited for use in live virus vaccines, and pharmaceutical formulations.
Claims6
A vaccine formulation comprising a genetically engineered attenuated equine influenza virus having an impaired interferon antagonist phenotype and a pharmaceutically acceptable carrier, wherein said virus comprises an equine influenza virus NS1 gene with a mutation resulting in a deletion of all of the amino acid residues of NS1 except amino acid residues 1-126.
Dependencies are inferred from the claim text.