Compositions comprising HPV polypeptides and immunoenhancement peptides for the treatment and prevention of cervical cancer
AssigneesPostech Foundation, Genexine, Inc.
InventorsYoung Chul Sung, Hyun Tak Jin, Sang Hwan Seo, Sang Hoon Park, Je-In Youn
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Abstract
The present invention relates to a fusion protein comprising a fusion polypeptide of E6 and E7 of a human papilloma virus, a signal peptide for secreting the polypeptide out of the cell, and an immune enhancing peptide for a subject; a polynucleotide encoding the fusion protein; and a vector containing the polynucleotide. The present invention further relates to a pharmaceutical composition comprising the fusion protein or the vector; and a method for treating a disease caused by a human papilloma virus using the pharmaceutical composition.
Claims4
A fusion protein comprising a fusion polypeptide of E6 and E7 of a human papilloma virus type 16 (HPV16), a signal peptide tPa (tissue plasminogen activator), and an immune enhancing peptide Flt3 (fms-like tyrosine kinase receptor-3) ligand for a subject, wherein the fusion polypeptide of E6 and E7 has the amino acid sequence of SEQ ID NO:
- 8 or SEQ ID NO:
- 14.
Dependencies are inferred from the claim text.