Nucleic acids and proteins from Streptococcus groups A & B
AssigneesNovartis Vaccines and Diagnostics, Inc., J. Craig Venter Institute, Inc.
InventorsJohn Telford, Vega Masignani, Maria Scarselli, Guido Grandi, Herve Tettelin, Claire Fraser
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Abstract
The invention provides proteins from group B streptococcus (Streptococcus agalactiae) and group A streptococcus (Streptococcus pyogenes), including amino acid sequences and the corresponding nucleotide sequences. Data are given to show that the proteins are useful antigens for vaccines, immunogenic compositions, and/or diagnostics. The proteins are also targets for antibiotics.
Claims20
An immunogenic S. agalactiae protein in substantially pure form comprising a fragment of 100 or more consecutive amino acids from the amino acid sequence SEQ ID NO:3746, wherein the protein binds to specific antibodies raised against an S. agalactiae protein comprising the amino acid sequence SEQ ID NO:3746, wherein the specific antibodies do not bind to unrelated antigens, and wherein the immunogenic S. agalactiae protein is an isolated protein or a recombinant protein.
A composition comprising:
- an immunogenic S. agalactiae protein in substantially pure form comprising a fragment of 100 or more consecutive amino acids from the amino acid sequence SEQ ID NO:3746, wherein the protein binds to specific antibodies raised against an S. agalactiae protein comprising the amino acid sequence SEQ ID NO:3746, wherein the specific antibodies do not bind to unrelated antigens;
- and
- an adjuvant.
Dependencies are inferred from the claim text.