Back to results
US 8,137,671 B2Granted
Anti-IL-17F antibodies
AssigneeGenentech, Inc.
InventorsKrzysztof Masternak, Francois Rousseau
Life of this patent
Estimating the term…
Abstract
This invention provides fully human monoclonal antibodies that recognize IL-17F and/or the heterodimeric IL-17A/IL-17F complex, but do not recognize IL-17A. The invention further provides methods of using such monoclonal antibodies as a therapeutic, diagnostic, and prophylactic.
Claims6
An isolated fully human monoclonal anti-IL-17F antibody, or fragment thereof, wherein said antibody comprises:
- (a) a VH CDR1 region comprising the amino acid sequence of SEQ ID NO:45,
- (b) a VH CDR2 region comprising the amino acid sequence of SEQ ID NO:46,
- (c) a VH CDR3 region comprising the amino acid sequence of SEQ ID NO:47,
- (d) a VL CDR1 region comprising the amino acid sequence of SEQ ID NO:74,
- (e) a VL CDR2 region comprising the amino acid sequence of SEQ ID NO:75, and
- (f) a VL CDR3 region comprising the amino acid sequence of SEQ ID NO:76, wherein said antibody binds IL-17F.
3 more elements
Dependencies are inferred from the claim text.