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AssigneeMedImmune, LLC
InventorsHerren Wu, Peter Kiener, Partha S. Chowdhury, James F. Young
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The present invention relates to the discovery of antibodies that bind to novel epitopes present on membrane-anchored IgE and which bind to these novel epitopes on the surface of B cells and plasma cells. In addition, the antibodies of the present invention can mediate ADCC and can be useful to deplete those B cells and plasma cells expressing the novel epitopes of the invention. The antibodies of the present invention can be useful for the treatment of IgE-mediated diseases. Accordingly the present invention also provides compositions and methods for the prevention, management, treatment or amelioration of IgE-mediated diseases.
An isolated antibody or antibody fragment which specifically binds the peptide sequence of SEQ ID NO:
An isolated nucleic acid sequence coding for an amino acid sequence selected from the group consisting of SEQ ID NO:
An isolated cell comprising at least one nucleic acid sequence selected from the group consisting of SEQ ID NO:
Dependencies are inferred from the claim text.