Elimination of heterogeneous or mixed cell population in tumors
AssigneeImmunoGen, Inc.
InventorsViktor S. Goldmakher, Robert J. Lutz, Ravi V. J. Chari, Yelena V. Kovtun, John M. Lambert, Rita Steeves, Hans K. Erickson
Life of this patent
Estimating the term…
Abstract
Methods of killing or inhibiting tumors comprising of heterogeneous or mixed cell populations is described. The killing or inhibition of tumors is achieved by selectively targeting a unique ligand suspected of being expressed on a particular cell population to also kill a cell population lacking the unique ligand. These conjugates have therapeutic use as they are delivered to a specific cell population to kill these cells and the cytotoxic drug is released to kill non-targeted cells, thereby eliminating the tumor.
Claims5
An isolated alkylated maytansinoid, which has the following formula:
- MayO(C═O)CH(Me)N(CH3)COCH2CH2(CMe2)nSMe
- wherein, n=1, and May=maytansinoid.
Isolated lysine-Nε-SPDB-DM4.
Isolated S-cysteinyl-DM4.
Isolated S-methyl-DM4.
Dependencies are inferred from the claim text.