Nattokinase for degrading and reducing amyloid fibrils—associated with alzheimer's disease, prion diseases and other amyloidoses
AssigneeAcademia Sinica
InventorsRita P.-Y. Chen, Kung-Ta Lee
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Abstract
A method of dissolving or disrupting pre-formed or pre-deposited amyloid fibrils and/or inhibiting amyloid formation, deposition, accumulation, or persistence in Alzheimer's disease, prion diseases and/or other amyloidoses in a mammalian subject is disclosed. In the method a therapeutically effective amount of nattokinase is administered.
Claims10
A method of dissolving or disrupting pre-formed or pre-deposited amyloid fibrils and/or inhibiting amyloid formation, deposition, accumulation, or persistence in an in vitro amyloid environment, the method comprising:
- adding to the in vitro environment a composition comprising an effective amount of nattokinase.
A method of catalyzing the degradation of amyloid fibrils comprising contacting in vitro amyloid fibrils with a composition comprising nattokinase in an amount effective to degrade the amyloid fibrils.
Dependencies are inferred from the claim text.