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US 8,137,657 B2Granted
Carrier particles for use in dry powder inhalers
AssigneeVectura Limited
InventorJohn Nicholas Staniforth
Life of this patent
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Abstract
In a method of producing particles suitable for use as carrier particles in dry powder inhalers, particles (1) of a size suitable for use as carrier particles in dry powder inhalers are treated so as to dislodge small grains from the surface of the particles, without substantially changing the size of the particles during the treatment. The treatment gives improved efficiency of redispersion of active particles from the surfaces of carrier particles.
Claims20
A method of producing particles for use as carrier particles in dry powder inhalers, the method comprising the steps of:
- selecting particles of a pharmacologically inert material or combination of materials, to obtain carrier particles having a diameter of between 50 μm and 1000 μm;
- milling the selected carrier particles to dislodge small grains from the surfaces of the selected particles without substantially changing the size of the selected carrier particles,
- wherein the step of selecting the size of the carrier particles occurs prior to the step of milling the selected particles;
- wherein the milling step is performed in a recirculated low fluid energy mill, and wherein the small grains become reattached to the surfaces of the carrier particles.
1 more element
Dependencies are inferred from the claim text.