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US 8,137,656 B2Granted
Method and apparatus for synthesis of [11C]phosgene using concentrated [11C] carbon monoxide with UV light
AssigneeGe Healthcare Limited
InventorsTor Kihlberg, Tommy Ferm, Bengt Langstrom
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Abstract
Methods and systems for labeling synthesis of phosgen by UV light are provided. Methods of synthesizing labeled compounds useful as PET tracers from labeled phosgen are also provided. The resultant carbon-isotope labeled compounds are useful as radio-pharmaceuticals, especially for use in Positron Emission Tomography. Associated kits for PET studies are also provided.
Claims6
A method for labeling synthesis of phosgene, comprising:
- (a) providing a UV reactor assembly comprising a high pressure reaction chamber and a UV light source, wherein the high pressure reaction chamber comprising a window facing a concave minor, a first gas inlet and a second gas inlet,
- (b) introducing a carbon-isotope monoxide enriched gas-mixture into the reaction chamber of the UV reactor assembly via the first gas inlet,
- (c) introducing Cl2 gas into the reaction chamber via the second gas inlet to obtain a Cl2-carbon-isotope monoxide gas mixture,
- (d) irradiating the Cl2-carbon-isotope monoxide gas mixture with UV light for an amount of time sufficient to promote the labeling synthesis, and
- (e) removing the labeled phosgene from the reaction chamber.
2 more elements
Dependencies are inferred from the claim text.