Thin collagen tissue for medical device applications
OwnerKemal Schankereliinventor
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Abstract
This invention relates to processes of preparing heterogeneous graft material from animal tissue. Specifically, the invention relates to the preparation of animal tissue, in which the tissue is cleaned and chemically cross-linked using both vaporized and liquid cross-linking agents, resulting in improved physical properties such as thin tissue and lowered antigenicity, thereby increasing the ease of delivering the tissue during surgery and decreasing the risk of post-surgical complication, respectively.
Claims8
A process of converting a pericardial tissue specimen taken from a bovine, porcine or ovine animal not more than 30 days old and comprised of 95-99% collagen, to a non-antigenic, non-thrombogenic, calcification-resistant implantable material for use in surgical procedures on humans consisting of the following steps performed in order:
- the pericardial tissue specimen is (i) cleaned, (ii) digested by surfactant, (iii) compressed to approximately 0.002″ (0.0508 mm) to 0.005″ (0.127 mm) in thickness by dehydration in a hyperosmotic solution, followed by mechanical compression, (iv) vapor cross-linked by exposing the tissue to a vapor-phase cross-linking agent selected from the group consisting of aldehydes, epoxides, isocyanates, carbodiimides, isothiocyanates, glycidalethers, and acyl azides, and (v) liquid-phase cross-linked by immersing the tissue in a liquid cross-linking agent selected from the group consisting of aldehydes, epoxides, isocyanates, carbodiimides, isothiocyanates, glycidalethers, and acyl azides.
A process of converting pericardial tissue specimen taken from a bovine, porcine or ovine animal not more than 30 days old and comprised of 95-99% collagen, to a non-antigenic, non-thrombogenic, calcification-resistant implantable material for use in surgical procedures on humans consisting of the following steps performed in order:
- the pericardial tissue specimen is (i) cleaned, (ii) digested by surfactant, (iii) compressed to approximately 0.002″ (0.0508 mm) to 0.005″ (0.127 mm) in thickness by dehydration in a hyperosmotic solution, followed by mechanical compression, (iv) vapor cross-linked by exposing the tissue to formaldehyde vapor for approximately 10 minutes, (v) further cross-linked by immersing in a glutaraldehyde solution for at least 24 hours and configured into a form.
Dependencies are inferred from the claim text.