Perm selective asymmetric hollow fibre membrane for the separation of toxic mediators from blood
AssigneeGambro Lundia AB
InventorsReinhold Buck, Hermann Goehl
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Abstract
The present invention relates to a permselective asymmetric hollow fibre membrane for the separation of toxic mediators from blood, comprised of at least one hydrophobic polymer and at least one hydrophilic polymer. Further, the present invention relates to a process for the preparation of such a membrane, and the use of said membrane in hemodialysis, hemodiafiltration, and hemofiltration for treatment of toxic mediator-related diseases.
Claims17
A permselective asymmetric hollow fibre membrane for the separation of toxic mediators from blood, comprised of at least one hydrophobic polymer and at least one hydrophilic polymer, wherein said hydrophobic polymer is selected from the group consisting of polyarylethersulfone (PAES), polypropylene (PP), polysulfone (PSU), polymethylmethacrylate (PMMA), polycarbonate (PC), polyacrylonitrile (PAN), polyamide (PA), and polytetrafluoroethylene (PTFE), and wherein said membrane comprises a separation layer and the separation layer is the inner most layer of the hollow fibre membrane, and wherein said membrane allows passage of molecules having a molecular weight of 50,000 Daltons, with a sieving coefficient of about 0.7 in the presence of whole blood, has a sieving coefficient for IL-6 in the presence of whole blood of 0.9-1.0, and has a molecular weight exclusion limit of about 200,000 Daltons in water;
- wherein the membrane allows the retention of a portion of albumin in the presence of whole blood.
A permselective membrane, comprised of at least one hydrophobic polymer and at least one hydrophilic polymer, wherein said membrane is provided with pores on the outer surface, wherein the average diameter of said pores is in the range of 0.5-3 μm and the number of said pores is in the range of 20,000 to 100,000 pores/mm2, further wherein the structure of said membrane:
- a) allows passage of molecules having a molecular weight of up to 45,000 Daltons, with a sieving coefficient of 0.1-1.0 in the presence of whole blood;
- b) has a sieving coefficient for IL-6 of 0.9-1.0 in the presence of whole blood;
- c) has a molecular weight exclusion limit of about 200,000 Daltons in water.
A permselective asymmetric hollow fibre membrane for the separation of toxic mediators from blood, comprised of at least one hydrophobic polymer and at least one hydrophilic polymer, wherein said membrane comprises a separation layer and the separation layer is the inner most layer of the hollow fibre membrane, and wherein said membrane allows passage of molecules having a molecular weight of 50,000 Daltons, with a sieving coefficient of 0.65 to 0.75 in the presence of whole blood, and has a molecular weight cut off of about 60,000 Daltons in the presence of whole blood;
- wherein the membrane allows the retention of a portion of albumin in the presence of whole blood.
Dependencies are inferred from the claim text.