Amide compound and thrombopoietin receptor activator

A compound represented by the formula (1), a tautomer thereof, or a pharmaceutically acceptable salt thereof:

• wherein
• A is a nitrogen atom or CH,
• when A is a nitrogen atom, B is NR9, wherein R9 is a C1-10 alkyl group, and
• when A is CH, B is a sulfur atom,
• R1 is a phenyl group, wherein said phenyl group is substituted with one or more substituents selected from the group consisting of:
• a halogen atom, an unsubstituted C1-10 alkyl group, a C1-10 alkyl group substituted with one or more halogen atom, an unsubstituted C1-10 alkoxy group, and a C1-10 alkoxy group substituted with one or more halogen atom,
• L1 is a bond,
• X is OH,
• R2 is a C1-6 alkyl group,
• L2 is a bond,
• L3 is NH,
• L4 is a bond or NH,
• Y is an oxygen atom or a sulfur atom, and
• R3 is
• a dihydrobenzo[1,4]dioxine group,
• a benzo[1,4]oxazinone group, and
• a thienyl group, wherein said thienyl group is substituted with a 2-(4-oxopyridin-1(4H)-yl)acetyl group) or a substituent represented by CONR29R30, where
• R29 is a hydrogen atom or a C1-10 alkyl group, and
• R30 is selected from the group consisting of
• an unsubstituted amino group,
• a pyridyl-substituted amino group,
• a mono-C1-10 alkylamino group,
• a di-C1-10 alkylamino group,
• a N-methylpiperazinyl group,
• a piperidino group,
• a morpholino group, and
• a C1-10 alkyl group substituted with one or more substituents selected from the group consisting of:
• a carboxyl group, a carbamoyl group, a pyrrolidinyl group, a tetrahydrofuryl group and a morpholino group, or
• R29 and R30 mean, together with each other, —(CH2)m3-G-(CH2)m4—, wherein
• G is CR31R32, wherein R31 is a hydrogen atom, and R32 is a C1-10 alkylcarbonylamino group or a pyrrolidinyl group, and each of m3 and m4 is independently an integer of from 0 to 5, provided that m3+m4 is 3, 4 or 5), or
• NR29R30, as a whole, is selected from the group consisting of a di-substituted piperidino group or a di-substituted pyrrolidinyl group, wherein the substitutents independently selected from the group consisting of:
• a hydroxyl group and a C1-10 alkoxy group.