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US 8,134,006 B2Granted
Dialkylphenyl compounds having β2 adrenergic receptor agonist and muscarinic receptor antagonist activity
AssigneeTheravance, Inc.
InventorsPierre-Jean Colson, Adam D. Hughes, Craig Husfeld, Mathai Mammen, Miroslav Rapta
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Abstract
This invention relates to compounds of formula I: wherein R1 and R2 are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The invention also relates to pharmaceutical compositions and combinations comprising such compounds, processes and intermediates for preparing such compounds, and methods of using such compound to, for example, treat pulmonary disorders, such as chronic obstructive pulmonary disease and asthma.
Claims8
A compound of formula III:
- wherein
- Y1 is selected from —CHO, —CN, —CH2OH, —CH(OR3a)OR3b, —C(O)OH, —C(O)OR3c, bromo and iodo, where R3a and R3b are selected independently from C1-6 alkyl, or R3a and R3b are joined to form C2-6 alkylene, R3c is selected from C1-6 alkyl;
- R1 is methyl or ethyl;
- R2 is methyl or ethyl;
- or a salt or stereoisomer thereof.
2 more elements
Dependencies are inferred from the claim text.