Imidazolyl pyrimidine inhibitor compounds

A compound selected from those of Formula (I) and pharmaceutically acceptable salts thereof:

• wherein
• R1, R2 and R3 are independently selected from the group consisting of H, halo, nitro, cyano, hydroxy, hydroxy(C1-10 alkyl), amino(C1-10 alkyl), haloalkyl, haloalkoxy, amino, azido, carboxyl, carbamoyl, mercapto, sulphamoyl, C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, C1-10 alkoxy, hydroxy(C1-10 alkoxy)(C1-10 alkoxy), (C1-10 alkoxy)(C1-10 alkoxy), (C1-10 alkoxy)(C1-10 alkyl), C1-10 alkanoyl, C1-10 alkanoyloxy, N—(C1-10 alkyl)amino, N,N—(C1-10 alkyl)2amino, C1-10 alkanoylamino, N—(C1-10 alkyl)carbamoyl, N,N—(C1-10 alkyl)2carbamoyl, C1-10 alkyl-S(O)a wherein a is 0, 1 or 2, C1-10 alkoxycarbonyl, NH2—S(O)2NH—, NH2—CO—NH—, N—(C1-10 alkyl)sulphamoyl, N,N—(C1-10 alkyl)2sulphamoyl, aryl, arylalkyl, aryloxy, arylthio, cycloalkyl, cycloalkylalkyl, cycloalkyloxy, heterocyclyl, heterocyclylalkyl, heterocyclyl(C═O)—, heterocyclyloxy and heterocyclylthio, wherein each R1 R2 and R3 is optionally substituted by one or more A;
• U1, U2, U3 and U4 are independently selected from —N—, —CH—, and —CR6—, with the proviso that at least one of U1, U2, U3 and U4 is —N—;
• m is 0, 1, 2, or 3;
• R6 is halo, hydroxy, nitro, cyano, trifluoromethyl, trifluoromethoxy, amino, carboxyl, carbamoyl, sulphamoyl, C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, C1-10 alkoxy, C1-10 alkanoyl, N—(C1-10 alkyl)amino, N,N—(C1-10 alkyl)2 amino, C1-10 alkanoylamino, N—(C1-10 alkyl)carbamoyl, N,N—(C1-10 alkyl)2 carbamoyl, C1-10 alkyl-S(O)a wherein a is 0, 1 or 2, NH2—S(O)2NH—, N—(C1-10 alkyl)sulphamoyl or N,N—(C1-10 alkyl)2sulphamoyl;
• wherein R6 is optionally substituted by one or more B;
• X is phenyl, 5-membered heteroaryl, or 6-membered heteroaryl, wherein the heteroaryl contains one or more heteroatoms selected from N, S and O;
• R7 represents one or more optional non-hydrogen substituents on ring X, wherein when present, each R7 is independently selected from hydroxy, halo, nitro, cyano, trifluoromethyl, trifluoromethoxy, amino, carboxyl, carbamoyl, sulphamoyl, C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, C1-10 alkoxy, C1-10 alkanoyl, N—(C1-10 alkyl)amino, N,N—(C1-10 alkyl)2 amino, C1-10 alkanoylamino, N—(C1-10 alkyl)carbamoyl, N,N—(C1-10 alkyl)2 carbamoyl, C1-10 alkyl-S(O)a wherein a is 0, 1 or 2, NH2—S(O)2NH—, N—(C1-10 alkyl)sulphamoyl, N,N—(C1-10 alkyl)2sulphamoyl, cycloalkyl, aryl and heterocyclyl;
• n is 0, 1, 2, 3 or 4;
• R8 is hydroxy, aryl or heteroaryl, wherein aryl or heteroaryl is substituted with —NH2 or —OH and aryl or heteroaryl is optionally further substituted with one or more groups selected from amino, halo, alkyl, alkenyl, alkynyl, haloalkyl, cycloalkyl, heterocyclyl, aryl, haloaryl, haloheterocyclyl, wherein alkyl, alkenyl, or alkynyl is optionally further substituted with one or more groups selected from halo, hydroxy, alkyl, haloalkyl and cycloalkyl;
• R9 is H, alkyl, haloalkyl, aminoalkyl, cycloalkyl, aryl, or heterocyclyl, wherein R9 is optionally substituted by one or more D;
• and
• A, B and D are independently selected from halo, nitro, cyano, hydroxy, oxo, hydroxyalkyl, haloalkyl, haloalkoxy, amino, azido, carboxyl, carbamoyl, mercapto, sulphamoyl, C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, C1-10 alkoxy, C1-10 alkanoyl, C1-10 alkanoyloxy, N—(C1-10 alkyl)amino, N,N—(C1-10 alkyl)2amino, C1-10 alkanoylamino, N—(C1-10 alkyl)carbamoyl, N,N—(C1-10 alkyl)2carbamoyl, C1-10 alkyl-S(O)a wherein a is 0, 1 or 2, C1-10 alkoxycarbonyl, N—(C1-10 alkyl)sulphamoyl, N,N—(C1-10 alkyl)2sulphamoyl, H2NS(O)2NH—, N—(C1-10 alkyl)NHS(O)2NH—, N,N—(C1-10 alkyl)2NS(O)2NH—, aryl, aryloxy, arylthio, cycloalkyl, cycloalkyloxy, heterocyclyl, heterocyclyl(C═O)—, heterocyclyloxy and heterocyclylthio.