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US 8,133,994 B2Granted
Preparation of aprepitant
AssigneeDr. Reddy's Laboratories, Inc.
InventorsPravinchandra Jayantilal Vankawala, Ravi Ram Chandrasekhar Elati, Naveen Kumar Kolla, Subrahmanyeswara Rao Chlamala, Srinivas Gangula
Life of this patent
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Abstract
A process for preparing aprepitant.
Claims14
A process comprising reducing a compound having the formula:
- or a salt thereof, with a chemical reducing agent to form a compound having the formula:
- wherein the chemical reducing agent is sodium borohydride, potassium borohydride, sodium dihydro-bis-(2-methoxyethoxy)aluminate, sodium cyanoborohydride, or sodium triacetoxyborohydride.
A process comprising reducing a compound having the formula
- or a salt thereof, with a chemical reducing agent to form a compound having the formula:
- wherein the chemical reducing agent is sodium borohydride, potassium borohydride, sodium dihydro-bis-(2methoxyethoxy)aluminate, sodium cyanoborohydride, or sodium triacetoxyborohydride,
- further comprising reacting the compound having the formula:
- with a compound having the formula:
- and heating a reaction product to form aprepitant.
2 more elements
A process comprising reducing a compound having the formula
- or a salt thereof, with a chemical reducing agent to form a compound having the formula:
- wherein the chemical reducing agent is sodium borohydride, potassium borohydride, sodium dihydro-bis-(2methoxyethoxy)aluminate, sodium cyanoborohydride, or sodium triacetoxyborohydride,
- further comprising reacting the compound having the formula:
- with a compound having the formula:
- to form a mixture of optical isomers and resolving a mixture to recover aprepitant.
2 more elements
Dependencies are inferred from the claim text.