Agonistic binding molecules to the human OX40 receptor
AssigneeCrucell Holland B.V.
InventorsAlexander Berthold Hendrik Bakker, Pauline Marie Louise Meester-Rood, Adrianus Quirinus Bakker
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Abstract
The present invention provides binding molecules, such as human binding molecules, that bind to and stimulate the human OX40-receptor. The invention also provides nucleic acids encoding such binding molecules. Methods for producing such binding molecules are also provided by the present invention. The binding molecules and nucleic acids are useful in the stimulation of human T-cells and can be used to enhance antigen-specific immune responses.
Claims13
A human binding molecule, which is isolated, consisting essentially of an agonistic binding molecule able to bind to and stimulate a human OX40-receptor, wherein the binding molecule has a synergistic stimulatory effect when co-incubated with OX40-ligand, and wherein the binding molecule comprises a heavy chain variable region comprising:
- the variable region of SEQ ID NO:25, or a molecule that is at least 97% homologous thereto, and
- a light chain variable region comprising the variable region of SEQ ID NO:
- 29, or a molecule that is at least 97% homologous thereto;
- or
- the variable region of SEQ ID NO:28, or a molecule that is at least 97% homologous thereto, and
- a light chain variable region comprising the variable region of SEQ ID NO:
- 32 or a molecule that is at least 97% homologous thereto.
A human binding molecule, which is isolated and consists essentially of an agonistic binding molecule able to bind and stimulate a human OX40-receptor, wherein the binding molecule is selected from the group consisting of a binding molecule comprising a heavy chain variable region comprising the variable region of SEQ ID NO:25, and a light chain variable region comprising the variable region of SEQ ID NO:
- 29;
- and a binding molecule comprising a heavy chain variable region comprising the variable region of SEQ ID NO:28, and a light chain variable region comprising the variable region of SEQ ID NO:
- 32.
An isolated binding molecule comprising:
- a heavy chain complementary determining region 3 comprising SEQ ID NO:17,
- a heavy chain variable region comprising the variable region of SEQ ID NO:25, and
- a light chain variable region comprising the variable region of SEQ ID NO:
- 29.
Dependencies are inferred from the claim text.