Polymer-factor VIII moiety conjugates
AssigneeNektar Therapeutics
InventorsMary J. Bossard, Michael D. Bentley, Ping Zhang
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Abstract
Conjugates of a Factor VIII moiety and one or more water-soluble polymers are provided. Typically, the water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided are compositions comprising the conjugates, methods of making the conjugates, and methods of administering compositions comprising the conjugates to a patient.
Claims33
A unit dose of a pharmaceutical composition comprising (i) a conjugate comprising one, two or three water-soluble polymers selected from the group consisting of a poly(alkylene glycol), a poly(oxyethylated polyol), a poly(olefinic alcohol), a poly(vinylpyrrolidone), a poly(hydroxyalkylmethacrylamide), a poly(hydroxyalkylmethacrylate), a poly(saccharide), a poly(α-hydroxy acid), a poly(vinyl alcohol), a polyphosphazene, a polyoxazoline, a poly(N-acryloylmorpholine), and combinations of any of the foregoing, covalently attached to a Factor VIII polypeptide selected from the group consisting of Factor VIII, Factor VIIIa, Factor VIII:C, Factor VIII:vWF and B-domain deleted Factor VIII, and (ii) a pharmaceutically acceptable excipient, wherein the Factor VIII polypeptide is present in an amount ranging from 0.001 mg to 100 mg.
Dependencies are inferred from the claim text.