Coagulation factor VII polypeptides
AssigneeNovo Nordisk Health Care A/G
InventorHenrik Østergaard
Life of this patent
Estimating the term…
Abstract
The present invention relates to novel coagulation Factor VII polypeptides, polynucleotide constructs encoding such polypeptides, as well as vectors and host cells comprising and expressing the polynucleotide, pharmaceutical compositions, uses and methods of treatment.
Claims20
An isolated Factor VII variant polypeptide comprising one or more additional N-glycosylation sites N-Xaa-S/T compared to the sequence of wild-type Factor VII (SEQ ID NO:1), wherein said additional glycosylation sites are introduced by amino acid substitutions at amino acids selected from the group consisting of Q64, I69, F71, P74, E77, G78, Q88, F275, M306, T307, and D309 of SEQ ID NO:
- 1, wherein Xaa is any amino acid except P, and wherein said variant polypeptide exhibits decreased Tissue Factor binding affinity compared to wild-type Factor VII.
Dependencies are inferred from the claim text.