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US 8,133,968 B2Granted
Poly(orthoester) polymers, and methods of making and using same
AssigneeMedtronic, Inc.
InventorsJulie A. Alkatout, Michael Eric Benz, Randall V. Sparer
Life of this patent
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Abstract
Poly(orthoester) polymers, and methods of making and using such poly(orthoester) polymers are provided. The poly(orthoester) polymers can be useful for applications including, for example, medical devices and pharmaceutical compositions. In a preferred embodiment, the poly(orthoester) polymers are biodegradable.
Claims18
A method of preparing a polymer, the method comprising:
- combining components comprising:
- at least one hydroxy-containing compound of the formula (Formula I)
- HO-A-OH;
- and
- at least one orthoester of the formula (Formula II)
- under conditions effective to polymerize at least a portion of the orthoester;
- and
- removing byproducts comprising R14OH to provide a polymer comprising two or more repeat units of the formula (Formula VI):
- wherein each R9 and R10 independently represents hydrogen or an organic group;
- each R11, R13, and R14 independently represents an organic group;
- n=0;
- each A independently represents a group of the formula (Formula III) —Ar2—C(R8)2—Ar2—(B)m—;
- and
- wherein each Ar2 independently represents an arylene group, each R8 independently represents a methyl group, B represents an aromatic-containing organic group having a linking oxygen attached to the aromatic ring, and m=0 or 1, wherein at least one A represents a structure of the formula:
11 more elements
Dependencies are inferred from the claim text.