Demulsifiers and methods for use in pharmaceutical applications
AssigneeRhodia Operations
InventorsRuela Talingting-Pabalan, Manilal S. Dahanayake, Gary Woodward, Herve Adam
Life of this patent
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Abstract
Demulsifiers containing an anionic surfactant selected from alkylsulfosuccinates, alkylsulfonates, alkylphosphonic acids, and their salts; a nonionic surfactant selected from ethylene oxide/propylene oxide copolymers, ethoxylated fatty acids of polyethylene glycol, terpene alkoxylates, and modified alkanolamides; or a combination of an anionic and a nonionic surfactant, and methods of use thereof in breaking emulsions.
Claims25
A composition comprising a pharmaceutical and a demulsifier comprising:
- an anionic surfactant selected from the group consisting of alkylsulfosuccinates, alkylsulfonates, alkylphosphonic acids, salts thereof, and combinations thereof;
- and a nonionic surfactant selected from the group consisting of ethylene oxide/propylene oxide copolymers, ethoxylated fatty acid esters of polyethylene glycol, terpene alkoxylates, modified alkanomides, and combinations thereof.
A demulsifier composition useful for demulsifying a pharmaceutical composition comprising an anionic surfactant selected from the group consisting of alkylsulfosuccinates, alkylsulfonates, alkylphosphonic acids, salts thereof, and combinations thereof;
- and a non-ionic surfactant is a terpene alkoxylate having the following formula:
- wherein R6 is methyl or ethyl, “n” is from about 20 to about 30, and “m” is from 0 to about 20.
A demulsifier composition useful for demulsifying a pharmaceutical composition comprising an anionic surfactant selected from the group consisting of alkylsulfosuccinates, alkylsulfonates, alkylphosphonic acids, salts thereof, and combinations thereof;
- and a terpene alkoxylate having the following formula:
- wherein R6 is methyl or ethyl, “n” is from about 20 to about 30, and “m” is from 0 to about 20.
A method for breaking an emulsion produced in the preparation of pharmaceuticals, the emulsion comprising a pharmaceutical, comprising contacting the emulsion with a demulsifier comprising
- (a) an anionic surfactant selected from the group consisting of alkylsulfosuccinates, alkylsulfonates, alkylphosphonic acids, salts thereof, and combinations thereof;
- (b) a nonionic surfactant selected from the group consisting of ethylene oxide/propylene oxide copolymers, ethoxylated fatty acids of polyethylene glycol, terpene alkoxylates, modified alkanolamides, and combinations thereof;
- or
- (c) a combination of (a) and (b).
Dependencies are inferred from the claim text.