Aqueous pharmaceutical compositions of 2,6-diisopropylphenol (propofol) and their uses

An aqueous formulation consisting essentially of, on a gram per 100 ml (reported as %) basis:

• 1-2% 2,6-diisopropylphenol;
• water;
• and up to 15% excipients, wherein the excipients consist essentially of about 4% polyethylene glycol (PEG), about 1% propylene glycol, about 5% poloxamer 188, about 1.5% polysorbate 80, and optionally, one or more pH modifiers, stabilizers, or tonicity modifiers, and wherein the formulation is an aqueous solution including less than 1% lipids and being clear to the naked eye.

An aqueous formulation consisting essentially of, on a gram per 100 ml (reported as %) basis:

• about 1% 2,6-diisopropylphenol, water, and up to 15% excipients, wherein the excipients consist essentially of about 6% polyethylene glycol (PEG), about 6% poloxamer 188, and optionally, one or more pH modifiers, stabilizers, or tonicity modifiers, wherein the formulation is an aqueous solution including less than 1% lipids and being clear to the naked eye.

An aqueous formulation consisting essentially of, on a gram per 100 ml (reported as %) basis:

• about 1% 2,6-diisopropylphenol;
• water;
• and up to 15% excipients, wherein the excipients consist essentially of about 6% polyethylene glycol (PEG), about 3% poloxamer 237, and optionally, one or more pH modifiers, stabilizers, or tonicity modifiers, wherein the formulation is an aqueous solution including less than 1% lipids and being clear to the naked eye.

An aqueous formulation consisting essentially of, on a gram per 100 ml (reported as %) basis:

• about 1-2% 2,6-diisopropylphenol;
• water;
• and up to 15% excipients, wherein the excipients consist essentially of about 2% to about 6% polyethylene glycol (PEG), about 5% to about 9% poloxamer 188, at least one preservative, and optionally, one or more antimicrobial agents, pH modifiers, stabilizers, or tonicity modifiers, and wherein the formulation is an aqueous solution including less than 1% lipids and being clear to the naked eye.