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AssigneesThe United States of America as represented by the Secretary of Agriculture, The University of Mississippi
InventorsAgnes M. Rimando, Dennis R. Feller, Wallace H. Yokoyama
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Resveratrol, a stilbenoid antioxidant found in grapes, wine, peanuts and other berries, has been reported to have hypolipidemic properties. Resveratrol and its three analogs (pterostilbene, piceatannol and resveratrol trimethyl ether) were evaluated for their effects on the activation of the peroxisome proliferator-activated receptor alpha (PPARα) isoforms, a receptor shown to mediate the activity of lipid-lowering drugs such as the fibrates. The four stilbenes and ciprofibrate (positive control) were evaluated for the activation of endogenous PPARα in H4IIEC3 cells. Pterostilbene demonstrated the highest induction of PPARα demonstrating increases of 7- and 9-14 fold relative to control. The maximal responses to pterostilbene are similar to those obtained with the hypolipidemic drug, ciprofibrate; that is, pterostilbene acts as a PPARα agonist, like that of the fibrate class, and is a more effective hypolipidemic agent than resveratrol.
A method of lowering lipid levels in an individual comprising administering to an individual in need thereof a therapeutically effective amount of an edible pharmaceutical composition consisting of an edible therapeutically effective unit dosage of isolated or chemically-synthesized pterostilbene and a pharmaceutically acceptable carrier, wherein the unit dosage of pterostilbene administered orally is effective to lower lipid levels in an individual.
A method of treating dyslipidemias in an individual at risk of cardiovascular disease by administering to an individual in need thereof a therapeutically effective amount of an edible pharmaceutical composition consisting of an edible therapeutically effective unit dosage of isolated or chemically-synthesized pterostilbene for lowering lipid levels in an individual and a pharmaceutically acceptable carrier, wherein the unit dosage of pterostilbene administered orally is effective to treat dyslipidemias or reduce the risk of dyslipidemias in an individual.
A method of lowering lipid levels in an individual comprising administering to an individual in need thereof an effective amount of an edible nutraceutical composition consisting of an edible therapeutically effective unit dosage of isolated or chemically-synthesized pterostilbene and a nutraceutically acceptable carrier, wherein the unit dosage of pterostilbene administered orally is effective to lower lipid levels in an individual and to treat or reduce the risk of dyslipidemias in an individual.
Dependencies are inferred from the claim text.