Thiophene derivatives as S1P1/EDGE1 receptor agonists

A compound of the Formula (I),

• wherein
• A represents *—CO—CH2CH2—, *—CO—CH═CH—,
• wherein the asterisks indicate the bond that is linked to the thiophene group of Formula (I);
• R1 represents C2-5-alkyl;
• R2 represents hydrogen, methyl or ethyl;
• R3 represents hydrogen;
• R4 represents methyl, ethyl, or methoxy;
• R5 represents —CH2—(CH2)n—NHSO2R51, —(CH2)nCH(OH)—CH2—NHSO2R51, —CH2—(CH2)n—NHCOR52, —(CH2)nCH(OH)—CH2—NHCOR52, —CH2—(CH2)n—CONR53R54, —CO—NHR53, 1-(3-carboxy-azetidinyl)-2-acetyl, 1-(2-carboxy-pyrrolidinyl)-2-acetyl, 1-(3-carboxy-pyrrolidinyl)-2-acetyl, 1-(3-carboxy-azetidinyl)-3-propionyl, 1-(2-carboxy-pyrrolidinyl)-3-propionyl, 1-(3-carboxy-pyrrolidinyl)-3-propionyl, hydroxy, hydroxy-C2-5-alkoxy, di-(hydroxy-C1-4-alkyl)-C1-4-alkoxy, 2,3-dihydroxypropoxy, 2-hydroxy-3-methoxy-propoxy, —OCH2—(CH2)m—NHSO2R51, —OCH2—CH(OH)—CH2—NHSO2R51, —OCH2—(CH2)m—NHCOR52, or —OCH2—CH(OH)—CH2—NHCOR52;
• R51 represents C1-3-alkyl, methylamino, ethylamino, or dimethylamino;
• R52 represents hydroxymethyl, 2-hydroxyethyl, 2-hydroxy-1-hydroxymethyl-ethyl, or 2,3-dihydroxypropyl;
• R53 represents hydrogen, C1-3-alkyl, 2-hydroxyethyl, 2-hydroxy-1-hydroxymethyl-ethyl, 2,3-dihydroxypropyl, carboxymethyl, 1-(C1-5-alkylcarboxy)methyl, 2-carboxyethyl, or 2-(C1-5-alkylcarboxy)ethyl;
• R54 represents hydrogen, or methyl;
• m represents the integer 1 or 2;
• n represents 0, 1, or 2;
• and
• R6 represents methyl, ethyl or halogen;
• in free or salt form.