Heteroaromatic monoamides as orexinin receptor antagonists

A pharmaceutical composition comprising a compound of formula I

• wherein
• i) Ar1 is heteroaryl;
• Ar2 is phenyl and
• Ar is phenyl or heteroaryl;
• or
• ii) Ar1 is phenyl;
• Ar2 is heteroaryl and
• Ar is phenyl or heteroaryl;
• or
• iii) Ar1 is heteroaryl;
• Ar2 is heteroaryl and
• Ar is phenyl or heteroaryl;
• R1 is hydrogen, halogen, lower alkyl, lower alkyl substituted by halogen or lower alkoxy;
• R2 is hydrogen, halogen, lower alkyl, lower alkyl substituted by halogen, lower alkoxy or lower alkoxy substituted by halogen;
• each R3 is independently hydrogen, halogen, lower alkyl, lower alkyl substituted by halogen, lower alkyl substituted by hydroxy, lower alkyl substituted by cycloalkyl, C(O)O-lower alkyl, C(O)NH-lower alkyl, —(CH2)m—O-lower alkyl, lower alkoxy, lower alkoxy substituted by halogen, cyano, SO2-lower alkyl, cycloalkyl, or
• where Ar2 is phenyl and o is 2, R3 optionally is R3 and R3′ which together with the corresponding carbon atoms to which they are attached form a non aromatic ring containing the groups —(CH2)4—, —(CH2)3—, —CH2—S(O)2—CH2—, —N(CH3)—C(O)—N(CH3)—, —(CH2)2—O—, —O—(CH2)2—O—, —O—(CH2)2—CH(OH)—, —O—(CH2)2—, —O—(CH2)3—, —O—CH2—C(O)—N(CH3)—, —N(CH3)—C(O)—(CH2)2—, or —O—C(CH3)2—O—;
• R4 and R5 are each independently hydrogen, hydroxy, lower alkyl, lower alkoxy, CH2NH2, O—C(O)-lower alkyl, or —NRR′ or R4and R5 together are ═O;
• R and R′ are each independently hydrogen, —S(O)2-lower alkyl, cycloalkyl, —(CH2)m—OH, —(CH2)m—O-lower alkyl, —C(O)CH(NH2)-phenyl, or oxetan-3-yl optionally substituted by CH2NH2, or
• R and R′ together with the N atom to which they are attached form a heterocycloalkyl ring, optionally containing in addition to the N atom a further heteroatom, selected from the group consisting of N, S and O;
• n is 1, 2 or 3;
• o is 1, 2 or 3;
• p is 1, 2 or 3;
• and
• m is 0, 1 or 2;
• or a pharmaceutically suitable acid addition salt, optically pure enantiomer, racemate or diastereomeric mixture thereof and a pharmaceutically acceptable carrier.