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US 8,133,904 B2Granted
Cannabinoid receptor antagonists/inverse agonists useful for treating obesity
AssigneeJenrin Discovery
InventorsJohn F. McElroy, Robert J. Chorvat
Life of this patent
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Abstract
The present invention provides novel pyrazoles that are useful as cannabinoid receptor antagonists and pharmaceutical compositions thereof and methods of using the same for treating obesity, diabetes, and/or cardiometabolic disorders.
Claims14
A compound selected from the following compounds 5, 6, 7, 10, 11, and 12 as follows:
- Ex. #
- X
- Z
- Y
- 4
- H
- 3-CONH2
- OMe
- 5
- CN
- 3-CONH2
- Cl
- 6
- CN
- 3-CO2Et
- OMe
- 7
- CONH2
- 3-CO2Et
- Cl
- 9
- H
- 3-CO2Et
- OCH3
- 10
- H
- 4-CH2CH2CH2CO2H
- Cl
- 11
- H
- 4-CH2CH2CH2CONH2
- OCH3
- 12
- H
- 3-CONHOH
- Cl
- or a pharmaceutically acceptable salt thereof.
34 more elements
Dependencies are inferred from the claim text.