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US 8,133,897 B2Granted
Phenylimidazole derivatives as PDE10A enzyme inhibitors
AssigneeH. Lundbeck A/S
InventorsAndreas Ritzén, Jan Kehler, Morten Langgård, Jacob Nielsen, John Paul Kilburn
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Abstract
This invention is directed to phenylimidazole compounds, which are PDE10A enzyme inhibitors useful for the treatment of neurological and psychiatric disorders.
Claims16
A compound having the structure of formula I
- wherein HET is a heteroaromatic group of formula II
- optionally substituted on the carbon atoms of the pyrazine ring of the HET croup with up to three substituents R7-R9 individually selected from the group consisting of hydrogen, C1-C6 alkyl;
- halogen;
- cyano, halo(C1-C6)alkyl;
- aryl, alkoxy and C1-C6 hydroxyalkyl, and wherein * denotes the attachment point,
- -L- is selected from the group consisting of —CH2—CH2—, —S—CH2—, —CH2—S— and —CH═CH—,
- R1 is selected from the group consisting of H, C1-C6 alkyl;
- C1-C6 alkyl(C3-C8)cycloalkyl;
- C1-C6 hydroxyalkyl, CH2CN, CH2C(O)NH2, C1-C6 arylalkyl, and C1-C6 alkyl-heterocycloalkyl, and
- R2-R6 are selected individually from the group consisting of H, C1-C6 alkoxy and halogen,
- or a pharmaceutically acceptable acid addition salt thereof.
8 more elements
Dependencies are inferred from the claim text.