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US 8,133,896 B2Granted
Pyrimidine derivatives which are antagonist of the vitronectin receptor
AssigneeGalapagos NV
InventorsJean-Michel Lefrancois, Bertrand Heckmann
Life of this patent
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Abstract
A subject of the invention is the compounds of formula (I); in which R1, R2, R3, R4 and R have the meanings indicated in the description, their preparation process, their use as medicaments having an antagonist activity on the vitronectin receptor and the pharmaceutical compositions containing them.
Claims13
A compound of general Formula (I)
- wherein:
- G represents
- R1 represents an alkyl radical containing 1 to 4 carbon atoms in linear or branched chain, or an alkoxy radical containing 1-4 carbon atoms in linear or branched chain;
- R2 represents an alkyl radical containing 1-4 carbon atoms, or a —(CH2)0-2—OR5 group;
- R3 represents an —SO2R5 radical;
- R4 represents OH, or a (C1-C8)-alkoxy group;
- R5 represents a (C1-C8)-alkyl, or (C5-C14)-aryl group, which is unsubstituted or substituted with one or more R0 groups;
- and
- R0 represents a hydroxyl group, or a (C1-C4)-alkoxy group;
- as well as physiologically acceptable addition salts thereof.
7 more elements
Dependencies are inferred from the claim text.