Combination of brimonidine and timolol for topical ophthalmic use
AssigneeAllergan, Inc.
InventorsChin-Ming Chang, Gary J. Beck, Cynthia C. Pratt, Amy L. Batoosingh
Life of this patent
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Abstract
Disclosed are pharmaceutical compositions comprising brimondine and timolol for topical ophthalmic delivery and a method of treatment comprising administering said composition when indicated for glaucoma and associated conditions such as elevated intraocular pressure in the eyes of humans.
Claims15
A method of treating a patient exhibiting elevated intraocular pressure (IOP), the method comprising administering twice daily to an affected eye a composition comprising 0.2% w/v, brimonidine and 0.5% w/v, timolol in a single composition, wherein said method results in a lower incidence of one or more adverse events, as compared to brimonidine in the absence of timolol, where the adverse event is selected from the group consisting of oral dryness, eye pruritus, foreign body sensation, allergic conjunctivitis, somnolence and conjunctival folliculosis.
A method of reducing elevated intraocular pressure associated with glaucoma or ocular hypertension comprising administering twice daily to an affected eye a single composition comprising both 0.2% w/v brimonidine tartrate and about 0.5% w/v timolol, wherein the method results in a lower incidence of oral dryness, eye pruritus, allergic conjunctivitis, foreign body sensation, somnolence, or conjunctival folliculosis as compared to using 0.2% w/v brimonidine tartrate in the absence of timolol.
Dependencies are inferred from the claim text.