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US 8,133,887 B2Granted
Oxaphenanthrene derivatives
AssigneeMerck Patent GmbH
InventorsAndreas Taugerbeck, Detlef Pauluth, Beate Kretschmer, Hanns Wurziger, Axel Jansen, David Maillard
Life of this patent
Estimating the term…
Abstract
The invention relates to compounds of the formula (I), in which R1, R2, R3, R4, Y and A have the meanings indicated, and to processes for the preparation thereof and to the use thereof for the preparation of medicaments.
Claims18
A compound of formula I
- in which
- A denotes a saturated or partially unsaturated carbocyclic or heterocyclic radical having 6 ring members, in which, in the case of saturated radicals, one or more CH2 groups may be replaced by CO,
- R1, R2,
- R3, and R4 independently of one another, denote H, Hal, branched or unbranched alkyl having 1 to 12 C atoms, in which one or more H atoms may be replaced by F, one or more CH2 groups may be replaced by —C═C—, —C≡C—, C═O, —O—, —S—, —NH—, —N-alkyl- or substituted or unsubstituted phenylene, and one or more CH3 groups may be replaced by
- in which z denotes CHR5, S, O, or NR5,
- Hal denotes fluorine, chlorine, bromine or iodine,
- Y denotes O, S or NR5;
- R5 denotes H or alkyl,
- or a pharmaceutically acceptable salt or solvate thereof, or an isolated stereoisomer thereof or a mixture thereof.
6 more elements
A compound selected from the group consisting of compounds of formulae I1 to I39 and Ia:
- wherein
- X denotes OH, O-alkyl or N(R5)2
- Y denotes OH, O-alkyl, COOR5 or CON(R5)2
- A denotes NHCH2C≡C—R5 or NHCH2HC═CH—R5
- R5 denotes H or alkyl,
- Q denotes O, NH, N-alkyl or CH2,
- and n is an integer of 1-12,
- or a pharmaceutically acceptable salt or solvate thereof.
5 more elements
Dependencies are inferred from the claim text.