Heterobicyclic carboxamides as inhibitors for kinases

A compound of the formula IA

• wherein R1 is hydroxyl, lower-alkoxy-lower alkyl, lower alkylsulfonylamino, amino-lower alkylamino, N-mono- or N,N-di-(lower alkyl)amino-lower alkylamino, N-mono- or N,N-di-(lower alkyl)amino-carbonyl-amino-, piperazinyl-lower alkylamino, N-lower alkylpiperazinyl-lower alkylamino, hydrazine, mono- di- or tri-(lower alkyl)-substituted hydrazine,
• R2 is phenyl substituted by a substituent selected from the group consisting of phenoxy, piperazinyl-lower alkyl, lower-alkylpiperazinyl-lower alkyl, C3-C8-cycloalkyl-piperazinyl-lower alkyl, piperidinyl-lower alkyl, lower-alkylpiperidinyl-lower alkyl, piperidinyliden-lower alkyl, lower-alkylpiperidinyliden-lower alkyl, piperidinyloxy, lower alkylpiperidinyloxy, pyrrolidinyl, amino-pyrrolidinyl, N-mono- or N,N-di-lower alkylaminopyrrolidinyl and 9-lower alkyl-3,9-diazabicyclo[3.3.1]non-3-yl-lower alkyl, or in all cases by one of the mentioned substituents and in addition by a moiety selected from lower alkyl, C3-C8-cycloalkyl, halo, halo-lower alkyl, halo-lower alkoxy and lower alkoxy;
• or is 2H-pyrazolyl that is unsubstituted or substituted by lower alkyl and by one or two moieties independently selected from lower alkoxyphenyl and lower alkoxyphenylphenyl;
• or is phenyl substituted by one or two moieties independently selected from lower alkyl, C3-C8-cycloalkyl, halo, halo-lower alkyl, halo-lower alkoxy, or by lower alkoxy, or is 2H-pyrazolyl substituted by halophenyl and lower alkyl;
• or wherein R1 is halo, amino, lower alkylamino, lower alkanoylamino, lower alkoxycarbonylamino, C3-8cycloalkylcarbonyl amino or hydroxyl-lower alkyl and
• R2 is phenyl substituted by a substituent selected from the group consisting of phenoxy, piperazinyl-lower alkyl, lower-alkylpiperazinyl, lower-alkylpiperazinyl-lower alkyl, C3-C8-cycloalkyl-piperazinyl-lower alkyl, phenyl lower-alkyl piperaziyl, piperidinyl-lower alkyl, lower-alkylpiperidinyl-lower alkyl, amino piperidinyl, lower alkoxycarbonylamino piperidinyl, piperidinyliden-lower alkyl, lower-alkylpiperidinyliden-lower alkyl, piperidinyloxy, lower alkylpiperidinyloxy, pyrrolidinyl, amino-pyrrolidinyl, N-mono- or N,N-di-lower alkylaminopyrrolidinyl, N-mono- or N,N-di-lower alkylaminopyrrolidinyl lower alkyl, 1,1-dioxido-4-thiomorpholinyl, and 9-lower alkyl-3,9-diazabicyclo[3.3.1]non-3-yl-lower alkyl, or in all cases by one of the mentioned substituents and in addition by a moiety selected from lower alkyl, C3-C8-cycloalkyl, halo, halo-lower alkyl, halo-lower alkoxy and lower alkoxy;
• or is 2H-pyrazolyl that is unsubstituted or substituted by lower alkyl and by one or two moieties independently selected from lower alkoxyphenyl and lower alkoxyphenylphenyl;
• A, B and X are independently selected from C(R3) or N, with the proviso that X is C(R3), one of A and B is N and the other is C(R3);
• R3 is lower alkyl, halo or hydrogen;
• Y is O, S, S(O), S(O)2, CH2 or CH2—CH2;
• and
• W is absent or is lower alkylene;
• a tautomer and/or a salt thereof.