Non steroidal glucocorticoid receptor modulators

A compound according to formula I:

• or a pharmaceutically acceptable salt thereof, wherein
• R1 is H or (1-4C)alkyl;
• R2 is —C(O)R15 or —S(O)2R15;
• R3 is H, (1-4C)alkyl or —OR16;
• R4 is H, (1-4C)alkyl or —OR16;
• R6 is H, —C(H)NOR16;
• R7 is H, halogen or cyano;
• or R7 is (1-6C)alkyl, (2-6C)alkenyl or (2-6C)alkynyl, all three optionally substituted with OH, halogen or NH2;
• or R7 is —C(H)NOR16, —OR16, —C(O)OR16 or —C(O)R16;
• R8 is cyano;
• or R8 is (1-6C) alkyl, (2-6C)alkenyl, (2-6C)alkynyl or —O(1-6C)alkyl, all substituted with amino, hydroxyl or halogen;
• or R8 is (hetero)aryl, optionally substituted with cyano, halogen, (1-4C)alkyl, (1-4C)alkoxy or (1-4C)alkoxy(1-4C)alkyl;
• or R8 is —C(H)NOR16, —C(O)NHR17, —C(O)R18, —C(O)OR19, or —C(1-4C)alkylNOR21;
• R9 is H, halogen, cyano or (1-4C)alkyl optionally substituted with halogen
• R10 is H or (1-4C)alkyl;
• R11 is H;
• R12 is H, cyano or (1-4C)alkyl;
• R13 is H, (1-4C)alkyl, halogen or formyl;
• R14 is H, halogen, cyano, (1-4C)alkyl, (2-6C)alkenyl, C(O)R21 or (hetero)aryl;
• R15 is H;
• or R15 is (1-6C)alkyl, (2-6C)alkenyl, (2-6C)alkynyl, —O(2-6C)alkyl, —O(2-6C)alkenyl or —O(2-6C)alkynyl, all optionally substituted with one or more OH, halogen, cyano or (hetero)aryl;
• or R15 is (hetero)aryl, optionally substituted with (1-4C)alkyl, halogen, cyano, nitro or amino;
• or R15 is NH2, (di)(1-4C)alkylamino, (1-4C)alkyl(1-4C)alkoxyamine, (1-4C)alkylthio(1-4C)alkyl or (1-4C)alkoxy(1-4C)alkyl;
• each R16 independently is H, (1-6C)alkyl, (2-6C)alkenyl or (2-6C)alkynyl;
• R17 is H, (1-4C)alkoxy or (3-6C)cycloalkyl;
• or R17 is (1-6C)alkyl, optionally substituted with halogen;
• or R17 is (hetero)aryl, optionally substituted with halogen, (1-4C)alkyl or (1-4C)alkoxy;
• R18 is H, NH2, —C(O)R21 or —S(1-4C)alkyl;
• or R18 is (1-4C)alkyl, optionally substituted with OH, halogen or cyano;
• R19 is H or (1-6C)alkyl, optionally substituted with OH or halogen, and
• each R21 independently is H or (1-6C)alkyl.