Compounds for the treatment of hepatitis C

A compound of formula I

• where:
• R1 is CO2R5 or CONR6R7;
• R2 is furanyl, pyrrolyl, thienyl, pyrazolyl, isoxazolyl, isothiazolyl, imidazolyl, oxazolyl, thiazolyl, oxadiazolyl, triazolyl, or tetrazolyl;
• and R2 is substituted with 1 substituent selected from the group consisting of cycloalkyl, tetrahydrofuranyl, tetrahydropyranyl, phenyl, pyrimidinyl, pyrazinyl, pyridinonyl, benzimidazolyl, piperidinyl substituted with 0-1 alkyl substituents, and pyridinyl substituted with 0-1 alkyl substituents;
• and R2 is substituted with 1 substituent selected from CO2R5, CON(R12)2, and COR13;
• and R2 is substituted with 0-1 substituents selected from oxo, amino, alkyl, and haloalkyl;
• R3 is hydrogen, halo, alkyl, alkenyl, hydroxy, benzyloxy, or alkoxy;
• R4 is cycloalkyl;
• R5 is hydrogen or alkyl;
• R6 is hydrogen, alkyl, alkylSO2, cycloalkylSO2, haloalkylSO2, (R9)(R10)NSO2, or (R11)SO2;
• R7 is hydrogen or alkyl;
• R8 is hydrogen, alkyl, cycloalkyl, (cycloalkyl)alkyl, alkylcarbonyl, cycloalkylcarbonyl, haloalkylcarbonyl, alkoxycarbonyl, alkylSO2, cycloalkylSO2, haloalkylSO2, aminocarbonyl, (alkylamino)carbonyl, (dialkylamino)carbonyl, benzyl, benzyloxycarbonyl, or pyridinyl;
• R9 is hydrogen or alkyl;
• R10 is hydrogen or alkyl;
• R11 is azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, homopiperidinyl, homopiperazinyl, or homomorpholinyl, and is substituted with 0-1 alkyl substituents;
• R12 is hydrogen, alkyl, alkoxyalkyl, aminoalkyl, (alkylamino)alkyl, (dialkylamino)alkyl, or (R11)alkyl;
• R13 is azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, homopiperidinyl, homopiperazinyl, or homomorpholinyl, and is substituted with 0-3 substituents selected from halo, alkyl, cycloalkyl, alkoxyalkyl, amino, alkylamino, dialkylamino, R11, aminoalkyl, (alkylamino)alkyl, (dialkylamino)alkyl, (R11)alkyl, or CO2R5;
• or R13 is a [4.3.0] or [3.3.0] bicyclic diamine attached to the carbonyl through one nitrogen, and is substituted with 0-2 R8 substituents;
• R14 is hydrogen, alkyl, cycloalkyl, (cycloalkyl)alkyl, aminoalkyl, (alkylamino)alkyl, (dialkylamino)alkyl, or benzyl;
• R15 is hydrogen, alkyl, cycloalkyl, (cycloalkyl)alkyl, aminoalkyl, (alkylamino)alkyl, (dialkylamino)alkyl, or benzyl;
• or NR14R15 taken together is azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, N-(alkyl)piperazinyl, morpholinyl, thiomorpholinyl, homopiperidinyl, or homomorpholinyl;
• R16 is hydrogen or alkyl;
• R17 is hydrogen, alkyl, or cycloalkyl;
• and
• X is methylene, a bond, or absent;
• or a pharmaceutically acceptable salt thereof.