Compositions containing piperacillin and tazobactam useful for injection
AssigneePfizer Inc.
InventorsJonathan M. Cohen, Syed M Shah, Christian L. Ofslager, Mahdi B. Fawzi
Life of this patent
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Abstract
An aminocarboxylic acid chelating agent, preferably EDTA, or a salt thereof has been found to be useful for inhibiting particulate formation in piperacillin/tazobactam parenteral combinations. The composition may also contain a buffer, preferably citrate, and optionally an aminoglycoside. The product may be in the form of a frozen composition that can be thawed for use. The product may also be in the form of a cryodesiccated powder that can be reconstituted by addition of an aqueous vehicle to reform a solution.
Claims15
A pharmaceutical composition useful for the treatment or control of bacterial infections by parenteral administration, the composition comprising effective amounts of (a) piperacillin or a pharmaceutically acceptable salt thereof, (b) tazobactam or a pharmaceutically acceptable salt thereof and c) ethylenediaminetetraacetic acid (EDTA) or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.