Quinolone derivative or pharmaceutically acceptable salt thereof

A quinolone derivative represented by a formula (I) or a pharmaceutically acceptable salt thereof

• wherein
• R1:
• a cycloalkyl or lower alkylene-cycloalkyl, wherein the cycloalkyl in R1 may be substituted;
• R2:
• —H or a halogen;
• R3:
• —H, a halogen, —OR0 or —O-lower alkylene-aryl;
• R0:
• the same or different from each other and each represents —H or a lower alkyl
• R4:
• a lower alkyl, halogeno-lower alkyl, lower alkylene-cycloalkyl, cycloalkyl or heterocyclic group, wherein the cycloalkyl and heterocyclic group in R4 may respectively be substituted;
• R5:
• —NO2, —CN, a lower alkyl, lower alkenyl, halogeno lower alkenyl, -L-Ra, —C(O)R0, —O—Rb, —N(R6)2, lower alkylene-N(R6)(Rc), —N(R6)C(O)—Rd, lower alkylene-N(R6)C(O)—Rd, lower) alkylene-N(R0)C(O)O-lower alkyl, —N(R0)C(O)N(R0)—Re, lower alkylene-N(R0)C(O)N(R0)—Re, —N(R0)S(O)2N(R0)C(O)—Rd, —CH═NOH, cycloalkyl, heterocyclic group, (2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl or (4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl, wherein the cycloalkyl and heterocyclic group in R5 may respectively be substituted;
• R6:
• H, a lower alkyl, lower alkylene-CO2R0 or lower alkylene-P(O)(ORp)2, wherein the lower alkylene in R6 may be substituted;
• L:
• a lower alkylene or lower alkenylene which may respectively be substituted;
• Ra:
• —OR0, —CN, —O-lower alkylene-aryl, —O-lower alkylene-CO2R0, —C(O)R0, —CO2R0, —C(O)NHOH, —C(O)N(R6)2, —C(O)N(R0)-aryl, —C(O)N(R0)—S(O)2-lower alkyl, —C(O)N(R0)—S(O)2-aryl, —C(O)N(R0)—S(O)2-heterocyclic group, —NH2OH, —OC(O)R0, —OC(O)-halogeno-lower alkyl, —P(O)(ORp)2, an aryl or heterocyclic group, wherein the aryl and heterocyclic group in Ra may be substituted;
• Rp:
• R0, a lower alkylene-OC(O)-lower alkyl, lower alkylene-OC(O)-cycloalkyl, lower alkylene-OC(O)O-lower alkyl, lower alkylene-OC(O)O-cycloalkyl, or lower alkylene-heterocyclic group, wherein the heterocyclic group in Rp may be substituted;
• Rb:
• H, a cycloalkyl, aryl, heterocyclic group, lower alkylene-Rba or lower alkenylene-Rba, wherein the lower alkylene, lower alkenylene, cycloalkyl, aryl and heterocyclic group in Rb may be substituted;
• Rba:
• —OR0, —O—Si(lower alkyl)3, —CO2R0, —C(O)NHOH, —C(O)N(R0)2, —C(O)N(R0)—S(O)2-lower alkyl, —C(O)N(R0)—S(O)2-aryl, ═C(NH2)═NOH, —C(NH2)═NO—C(O)R0, —C(NH2)═NO—C(O)-lower alkylene-C(O)R0, —CO2-lower alkylene-aryl, —P(O)(ORp)2, —C(O)R0, —C(O)-aryl, a cycloalkyl, aryl or heterocyclic group, wherein the aryl and heterocyclic group in Rba may be substituted;
• Rc:
• H, a lower alkyl, lower alkylene-OR0, lower alkylene-CO2R0, lower alkylene-C(O)NHOH, lower)alkylene-C(O)N(R0)2, lower alkylene-P(O)(ORP)2, lower alkylene-aryl, lower alkylene-heterocyclic group, aryl or heterocyclic group, wherein the lower alkylene, aryl and heterocyclic group in Rc may be substituted;
• Rd:
• a C1-7 alkyl, lower alkenyl, halogeno-lower alkyl, lower alkylene-Rda, lower alkenylene-Rda, cycloalkyl, aryl or heterocyclic group, wherein the lower alkylene, lower alkenylene, cycloalkyl, aryl and heterocyclic group in Rd may be substituted;
• Rda:
• —CN, —OR0, —OC(O)R0, —O-lower alkylene-CO2R0, —O-aryl, —CO2R0, —C(O)NHOH, —C(O)N(R0)2, —CO2-lower alkylene-N(R0)2, —P(O)(ORP)2, —N(R6)2, —N(R0)C(O)R0, —C(O)N(R0)-aryl, —C(O)N(R0)-(lower alkylene which may be substituted with —CO2R0)-aryl, —N(R0)C(O)-aryl, —N(R0)C(O)—OR0, —N(R0)C(O)—O-lower alkylene-aryl, —N(R0)S(O)2-aryl, —S-heterocyclic group, —C(O)N(R0)-heterocyclic group, —N(R0)C(O)-heterocyclic group, a cycloalkyl, aryl or heterocyclic group, wherein the cycloalkyl, aryl and heterocyclic group in Rda may be substituted;
• Re:
• lower alkylene-CO2R0, lower alkylene-C(O)NHOH, lower)alkylene-C(O)N(R0)2, a lower alkylene-heterocyclic group, aryl, heterocyclic group, —S(O)2-aryl or —S(O)2-heterocyclic group, wherein the aryl and heterocyclic group in Re may be substituted;
• X:
• CH;
• A:
• C(R7);
• R7:
• —H or a lower alkyl, or R4 and R7 may together form a lower alkylene which may be substituted;
• with the proviso that 7-(cyclohexylamino)-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carbonitrile is excluded.