Carbohydrate conjugates to prevent abuse of controlled substances
AssigneeShire LLC
InventorsTravis Mickle, Thomas Piccariello, James Scott Moncrief, Nancy Johnston Boerth, Barney Bishop
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Abstract
The invention provides a “street-safe” version of a controlled substance that permits the therapeutically beneficial effects of the substance while reducing or eliminating the euphoric effects that lead to substance abuse. The invention provides pharmaceutical compositions comprising a controlled substance and a carbohydrate covalently bound to said controlled substance in a manner that renders said controlled substance pharmacologically inactive or substantially diminishes its activity and methods of using the same.
Claims3
An oral pharmaceutical composition comprising:
- hydrocodone;
- and
- a disaccharide covalently bound to the hydrocodone via an ester or carbonate bond through a hydroxyl group of the disaccharide and an oxygen atom in the hydrocodone in a manner that renders the hydrocodone pharmacologically inactive or substantially diminishes its activity until unbound hydrocodone is released.
An oral pharmaceutical composition comprising a disaccharide covalently bound to hydrocodone via an ester or carbonate group through a hydroxyl group of the disaccharide and an oxygen atom in the hydrocodone in a manner that renders the hydrocodone pharmacologically inactive or substantially diminishes its activity until the unbound hydrocodone is released, wherein the hydrocodone covalently bound to the carbohydrate has the formula:
A compound of the formula:
Dependencies are inferred from the claim text.