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US 8,133,878 B1Granted
Methods for treating restenosis
AssigneeThe General Hospital Corporation
InventorsRoger J. Hajjar, Anne-Marie Lompr, Larissa Lipskaia, Federica del Monte
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Abstract
Restenosis in a subject can be treated by administering to a tissue, e.g., a blood vessel, of the subject an agent that increases SERCA activity. For example, a stent that is coated with the agent can be introduced into a blood vessel.
Claims10
A method of reducing restenosis or stenosis in a subject comprising administering to an injured blood vessel, vein or artery of the subject a nucleic acid sequence that encodes a SERCA2a polypeptide, wherein the nucleic acid sequence is in a viral vector, thereby reducing the restenosis or stenosis.
Dependencies are inferred from the claim text.