Method for inhibiting scavenger receptor-A and increasing immune response to antigens
AssigneeHealth Research, Inc.
InventorsXiang-Yang Wang, John Subjeck
Life of this patent
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Abstract
Provided is a method for enhancing an immune response to a desired antigen in an individual. The method is performed by administering to the individual an agent capable of inhibiting class A macrophage scavenger receptor (SR-A) and optionally administering the desired antigen. Also provided is a method for enhancing an immune response to an antigen by administering to an individual a composition containing antigen presenting cells that are characterized by specifically inhibited SR-A. Substantially purified populations of mammalian dendritic cells characterized by specifically inhibited SR-A are also provided.
Claims4
A method for enhancing in an individual an immune response to a desired antigen comprising administering to the individual an effective amount of a composition comprising dendritic cells, wherein the dendritic cells are characterized by having specifically inhibited class A macrophage scavenger receptor (SR-A), wherein the SR-A activity of the dendritic cells is specifically inhibited by an shRNA that is targeted to SR-A mRNA, and wherein the administering the composition enhances the immune response to the desired antigen in the individual.
Dependencies are inferred from the claim text.