Oligonucleotide or its functional homologue, a composition comprising the same and a method of treating B cell neoplasm
AssigneeChangchun Huapu Biotechnology Co., Ltd.
InventorsLi-ying Wang, Mu-sheng Bao, Yong-li Yu
Life of this patent
Estimating the term…
Abstract
The invention provides an oligonucleotide with a sequence of SEQ ID NO: 1 or its functional homolgue, a composition comprising the same and a method for treating B cell neoplasm by using the oligonucleotide or its functional homologue or the composition comprising the oligonucleotide. The oligonulceotide induces the apoptosis of B cell neoplastic cells, up-regulates CD40 on B cell neoplastic cells and stimulates the production of IL-10 from B cell neoplastic cells.
Claims15
A method for treating B cell neoplasm in a mammalian subject, comprising administering to a subject in need of treating a therapeutically effective amount of a pharmaceutical composition comprising an oligonucleotide having the sequence of SEQ ID NO:
- 1.
A method of inducing apoptosis of B-cell neoplastic cells, comprising contacting said B-cell neoplastic cells with a composition comprising an oligonucleotide having the sequence of SEQ ID NO:
- 1.
A method for enhancing the expression of CD40 on B cell neoplastic cells, comprising contacting said B-cell neoplastic cells with a composition comprising an oligonucleotide having the sequence of SEQ ID NO:
- 1.
A method for inducing B cell neoplastic cells to produce IL-10, comprising contacting said B-cell neoplastic cells with a composition comprising an oligonucleotide having the sequence of SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.