Recombinant chemokine-antigen vaccine
AssigneeCancer Institute, Chinese Academy of Medical Sciences
InventorsShuren Zhang, Chen Lin, Wenxin Sun, Hanjun Qin, Chunxia Zhou, Xiao Liang, Dongmei Wang, Wenbo Ma, Xueyan Zhang, Ming Fu
Life of this patent
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Abstract
A recombinant gene sequence that comprises human SLC gene, antigen gene, and IgG1-Fc fragment gene, wherein the SLC gene is linked upstream to the antigen gene, and the IgG1-Fc fragment is linked downstream to the antigen gene. This invention also relates to the application of the recombinant gene sequence in the preparation of gene vaccine.
Claims9
A recombinant nucleic acid comprising a human secondary lymphoid tissue chemokine (SLC) gene, an antigen gene, and an IgG1-Fc fragment gene, wherein the SLC gene is linked upstream to the antigen gene, and the IgG1-Fc fragment gene is linked downstream to the antigen gene, wherein an E. coli RI (EcoRI) restrictive endonuclease site and nucleic acid residues encoding three glycine residues are present between the SLC gene and the antigen gene, and an E. coli RV (EcoRV) restrictive endonuclease site and nucleic acid residues encoding five glycine residues are present between the antigen gene and the IgG1-Fc fragment gene.
A polypeptide having the amino acid sequence encoded by the nucleic acid sequence set forth in SEQ ID NO:
- 1.
A polypeptide having the amino acid sequence set forth in SEQ ID NO:13.
Dependencies are inferred from the claim text.