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AssigneesThe Trustees of Columbia University in the City of New York, The Cleveland Clinic Foundation
InventorsDavid M. Stern, Ann Marie Schmidt, Steven Marso, Eric Topol, A. Michael Lincoff
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This invention provides for a method for inhibiting new tissue growth in blood vessels in a subject, wherein the subject experienced blood vessel injury, which comprises administering to the subject a pharmaceutically effective amount of an inhibitor of receptor for advanced glycation endproduct (RAGE) so as to inhibit new tissue growth in the subject's blood vessels. The invention also provides for method for inhibiting neointimal formation in blood vessels in a subject, wherein the subject experienced blood vessel injury, which comprises administering to the subject a pharmaceutically effective amount of an inhibitor of receptor for advanced glycation endproduct (RAGE) so as to inhibit neointimal formation in the subject's blood vessels. The invention also provides a method for preventing exaggerated restenosis in a diabetic subject which comprises administering to the subject a pharmaceutically effective amount of an inhibitor of receptor for advanced glycation endproduct (RAGE) so as to prevent exaggerated restenosis in the subject.
A method for inhibiting neointimal formation in blood vessels in a subject, wherein the subject experienced blood vessel injury, comprising administering to the subject a soluble fragment of a receptor for advanced glycation endproducts polypeptide which fragment is coupled to an antibody in an amount effective to inhibit neointimal formation in the subject's blood vessels.
Dependencies are inferred from the claim text.