Back to results
US 8,133,865 B2Granted
von Willebrand factor- and factor VIII-polymer conjugates having a releasable linkage
AssigneesNektar Therapeutics, Baxter International Inc., Baxter Healthcare S.A.
InventorsMary J. Bossard, Gayle Stephenson, Zhihao Fang, Harold Zappe, Stacy Mitchell, Ping Zhang, Friedrich Scheiflinger, Peter Turecek, Juergen Siekmann, Katalin Varadi, Herbert Gritsch
Life of this patent
Estimating the term…
Abstract
The present invention provides von Willebrand Factor-polymer conjugates and Factor VIII-polymer conjugates, each having a releasable linkage. Methods of making conjugates, methods for administering conjugates, are also provided.
Claims27
A compound having the following structure:
- wherein:
- POLY' is a first water-soluble polymer;
- POLY2 is a second water-soluble polymer;
- X1 is a first spacer moiety;
- X2 is a second spacer moiety;
- Hα is an ionizable hydrogen atom;
- R1 is H or an organic radical;
- R2 is H or an organic radical;
- (a) is either zero or one;
- (b) is either zero or one;
- Re1, when present, is a first electron altering group;
- Re2, when present, is a second electron altering group;
- Y1 is O or S;
- Y2 is O or S;
- and
- (vWF/F8) is a residue of an amine-containing biologically active agent selected from the group consisting of a von Willebrand Factor moiety and a Factor VIII moiety, wherein the amine-containing biologically active agent is liberated from the compound in its native form under physiological conditions and is bioactive.
13 more elements
Dependencies are inferred from the claim text.