Stabilizing alkylglycoside compositions and methods thereof
AssigneeAegis Therapeutics, LLC
InventorEdward T. Maggio
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Abstract
The present invention relates to alkylglycoside-containing compositions and methods for increasing the stability, reducing the aggregation and immunogenicity, increasing the biological activity, and reducing or preventing fibrillar formation of a peptide, polypeptide, or variant thereof, for example amylin, a monoclonal antibody, insulin, Peptide T or analog thereof, gastrin, gastrir releasing peptides, gastrin releasing peptide-like (GRP) proteins, epidermal growth factor or analog thereof.
Claims37
A liquid pharmaceutical composition for increasing the stability, reducing aggregation or reducing immunogenicity of octreotide or a variant thereof comprising:
- octreotide or a variant thereof;
- and
- a stabilizing agent comprising at least one alkylglycoside, with the proviso that the composition is free of naturally occurring variants of octreotide.
A method for increasing the stability of octreotide or a variant thereof comprising:
- admixing octreotide or a variant thereof, a stabilizing agent and a buffering agent to form a liquid composition, with the proviso that the composition is free of naturally occurring variants of octreotide, wherein the stabilizing agent is at least one alkylglycoside surfactant, thereby increasing the stability of the octreotide or variant thereof.
Dependencies are inferred from the claim text.